Sarajevo Canton Research Articles

Assessment and Application of the Hear Score in Remote Emergency Medicine Outposts in Bosnia and Herzegovina.

Background and Objectives. In emergency departments, chest pain is a common concern, highlighting the critical importance of distinguishing between acute coronary syndrome and other potential causes. Our research aimed to introduce and implement the HEAR score, specifically, in remote emergency outposts in Bosnia and Herzegovina. Materials and Methods. This follow-up study conducted a retrospective analysis of a prospective cohort consisting of patients who were admitted to the remote emergency medicine outposts in Canton Sarajevo and Zenica from 1 November to 31 December 2023. Results. This study comprised 103 (12.9%) patients with low-risk HEAR scores and 338 (83.8%) with high-risk HEAR scores, primarily female (221, 56.9%), with a mean age of 63.5 ± 11.2). Patients with low-risk HEAR scores were significantly younger (50.5 ± 15.6 vs. 65.9 ± 12.1), had fewer smokers (p < 0.05), and exhibited a lower incidence of cardiovascular risk factors compared to those with high-risk HEAR scores. Low-risk HEAR score for prediction of AMI had a sensitivity of 97.1% (95% CI 89.9-99.6%); specificity of 27.3% (95% CI 22.8-32.1%); PPV of 19.82% (95% CI 18.67-21.03%), and NPV of 98.08% (95% CI 92.80-99.51%). Within 30 days of the admission to the emergency department outpost, out of all 441 patients, 100 (22.7%) were diagnosed with MACE, with AMI 69 (15.6%), 3 deaths (0.7%), 6 (1.4%) had a CABG, and 22 (4.9%) underwent PCI. A low-risk HEAR score had a sensitivity of 97.0% (95% CI 91.7-99.4%) and specificity of 27.3% (95% CI 22.8-32.1%); PPV of 25.5% (95% CI 25.59-28.37%); NPV of 97.14% (95% CI 91.68-99.06%) for 30-day MACE. Conclusions. In conclusion, the outcomes of this study align with existing research, underscoring the effectiveness of the HEAR score in risk stratification for patients with chest pain. In practical terms, the implementation of the HEAR score in clinical decision-making processes holds significant promise.

Fertility Trends and Population Policy in the Canton of Sarajevo

The demography of Bosnia and Herzegovina fits into the Southeast-European trends with sub-replacement fertility and high emigration rates. At the national level, natural decline started in 2007, while migration is influenced by the war and its aftermath, as well as several economic and political push factors (low wages, corruption, high unemployment, etc.), and also has a serious impact on birth and death rates. On the other hand, demographic trends in the Canton of Sarajevo differ from the national pattern. It reached sub-replacement fertility more than a decade later (2019), and migration still has a positive balance: besides significant emigration rates, immigration to the Canton, especially from the other parts of Bosnia and Herzegovina, is higher. Since migration involves younger generations, it is also a factor behind the more favourable fertility rates, and can be evaluated as a consequence of better socio-economic development in the capital and its gravitational area. In the Canton, there have been several factors that contributed to the decline of birth rates in the past decades. Changing functions of family and children in the society, increasing women's employment, educational level and career aspirations, growing individualism and rationality, the changing social climate in relation to children, higher personal standards, and other socio-psychological factors should be mentioned. Birth rates were also (positively) influenced by other factors. One of the most important points is that the Canton has certainly one of the best support policies in Bosnia and Herzegovina including financial support and allowances for newborn children, subsidies in preschool education, primary and secondary schools as well as scholarships for pupils and students. Positive economic trends such as new constructions of residential buildings, business, and shopping centres, as well as an even stronger concentration of attractive institutions and activities should be emphasised. In 2021, the total fertility rate accounted for 1.38 in the Canton, while it has shown a great variation among the municipalities. The municipality with the lowest total fertility rate (Novi Grad) had the highest total number of live births in the Canton, while the municipality with the lowest total number of live births (Trnovo) was the only one with total fertility rate values above the replacement level. Due to its demographic, economic and political significance, the Canton of Sarajevo is a key area for population revitalisation in Bosnia and Herzegovina. Therefore, local measures have national significance, and can act as a model for the rest of the country in terms of population policy as well.

Impact of COVID-19 on mortality in the canton of Sarajevo in period 2020-2022

Background/Aim: Until March 2023, it has been reported over 676 million cases of COVID-19 globally with almost 7 million deaths caused by this disease. Aim of this study was to determine COVID-19-related deaths and to study how COVID-19 pandemic impacted mortality of residents in the Canton of Sarajevo in 2020-2022 time period. Also, aim was to analyse to what extent the number of registered non-COVID-19-related deaths have changed in the Canton of Sarajevo compared to what would have been expected in the absence of the virus to better measure the impact of COVID-19. Methods: This study used mortality data obtained from Federal Institute for Statistics for period 2017-2022. Data was analysed and presented as raw numbers, age-, sex-, cause of death - crude death rates (CDR), excess mortality and P-score. Results: CDR in the Canton of Sarajevo in 2020 was 1246.3 per 100.000 persons, 1488.6 in 2021 and 1153.4 in 2022, while in period from 2017-2019 CDR ranged from 1051.3 to 1057.9. Total CDR in 2020 increased by 18.3 % compared to 2017-2019 average CDR, this relative difference being even greater in 2021 (41.3 %) and lower in 2022 (9.5 %). In 2020-2022 time period, 9 of the 10 leading causes of death remained the same as in 2019. COVID-19 was the 3rd leading cause of death in 2020 and 2022, while in 2021 spiked as the leading cause of death. In 2020 there was increase of 7 % in deaths from non-COVID-19 related deaths compared to mean number of deaths for period 2017-2019. As for 2021, this number goes higher (9.5 %) and in 2022 was much lower (1.0 %). Conclusion: In the Canton of Sarajevo, COVID-19 pandemic made a big impact on mortality in 2020-2022 years period. Data have changed in total mortality, leading causes of death and excess mortality. Deep-rooted organisational weaknesses that were exposed during pandemic that can bring harm to population from preventable chronic diseases needs to be addressed which have impact on morbidity and at the end, on mortality.

OHCA in Bosnia and Herzegovina: Before and During the COVID-19 Pandemic.

Out-of-hospital cardiac arrest (OHCA) refers to the cessation of mechanical cardiac activity outside healthcare facilities which requires prompt intervention and intensive resuscitative efforts. The COVID-19 pandemic has caused significant disruptions to OHCA systems-of-care, adversely affecting every component of the chain of survival. The objective of this study was to examine the potential impacts of the COVID-19 pandemic on OHCA events, to draw comparisons between the period before and during the COVID-19 pandemic. This cross-sectional study encompassed data pertaining to all OHCA incidents attended to by the Emergency Medical Service of Canton Sarajevo, covering the period from January 2017 to December 2022, before and during the COVID-19 pandemic. During observed period, a total of 1418 [796 (56.1%) before and 622 (43.9%) during COVID-19 pandemic] OHCA events have occurred in Canton Sarajevo of which 297 (20.9 %) [180 (12.7%) before and 117 (8.2%) during COVID-19 pandemic] obtained ROSC. After a 30-day period following the ROSC) it was observed that the predominant outcome, accounting for 181 (12.7%) [106 (7.4%) before and 75 (5.2%) during COVID-19 pandemic] of cases, was a complete recovery. An examination before and during COVID-19 pandemic revealed a decline in OHCA during the year 2021 and 2022 when COVID-19 pandemic was at its highest in the country Being younger, quicker EMT response time and individuals with the initial rhythm of VF or VT were significantly associated with obtaining ROSC (p<0.05). Only 48 (3.3%) of 1418 OHCA events were assisted by bystanders There was no report of AED usage. In conclusion, our investigation highlights the impact of the COVID-19 pandemic on OHCA events in Canton Sarajevo, revealing a decrease in OHCA incidence and a reduction in cases achieving ROSC. Notably, EMT response time was shorter during the pandemic.

Reasons for Referring Patients for Determining the Hormonal Status of the Thyroid Gland From the Level of Primary Health Care in Sarajevo Canton.

Thyroid dysfunction includes hyper- and hypofunction of the thyroid gland (hyperthyroidism and hypothyroidism). The spectrum encompasses both subclinical and clinical disease presentation. The etiology is vast and varied, as are the risk factors and simptoms. The main aim of the research is to indicate the leading symptom for initial thyroid hormone status evaluation, as well as to identify the distribution of positive and negative test results, and specific disorders according to sex and age groups. The research is designed as a retrospective, clinical, descriptive study. There were 500 participants included, 355 female and 145 male. Patients were referred to the Department of endocrinology by their primary care physicians. The data was collected through patient documentation. The study included 500 participants, 71% of diagnostic requests made were for women. 80% of subjects had normal thyroid hormone status, p<0.001. Most requests were made for the 41-60 age group, p<0.001. Women had similar number of positive and negative test outcomes, as well as men. When it comes to the age groups, outcomes were similar in all of them, 15-23% positive and 77-85% negative. There were significant differences in the type of symptom expressed in both men and women, as well as all the age groups. Men reported high blood pressure as the most common symptom (30.3%), while women reported weight gain (22.3%). In the 18-25 and 26-40 age groups most common symptom belongs to the category of other. Age group of 41-60 reported weight gain as the most common symptom, while in participants older than 60, high blood pressure is proven to be the most common. Hypothyroidism is the most common disorder in both men and women, as well as in all age groups. It is statistically proven that there were more requests made for women, and older age groups. Leading symptom for initial thyroid hormone status evaluation is high blood pressure. There is no statistically significant difference in distribution of thyroid disorders according to sex or age groups.

Procena rizika u korelaciji sa gojaznošću i laboratorijskim monitoringom najčešćih tipova karcinoma dojke kod žena u Kantonu Sarajevo

Introduction: Breast cancer (BC) is a malignant disease that predominantly affects women, with known genetic components such as mutations in tumor suppressor genes BRCA1 and BRCA2. Other risk factors include unhealthy lifestyles, lack of physical activity, and consumption of alcohol and cigarettes. Aging also plays a role in BC development, with hormonal influences such as estrogen and progesterone promoting cancer growth. Material and Methods: Research was conducted using data collection tools for risk factors and tumor markers from primary healthcare unit records. The sample comprised 200 women, divided into two groups based on BC diagnosis, with complete medical documentation. Male BC cases were excluded. Results: Statistical significance was found between genetic components, family history, aging, obesity, alcohol and cigarette consumption, longer hormone exposure, and female BC development using the Chi-Square test, confirmed by Fisher's Exact test. Tumor markers CA 15-3, CEA, CA 19-9, and CA 125 were useful for BC screening and metastasis detection, as determined by the One Sample T-test. In Sarajevo Canton, invasive ductal BC was the most common type among women, while lobular carcinoma in situ was the least common. Conclusion: Correlations between risk factors, including aging, unhealthy lifestyles, and hormone exposure, and increased BC risk were confirmed. Tumor markers CA 15-3, CEA, CA 19-9, and CA 125 were effective in diagnosis, screening, and metastasis detection in females, with sensitivity for regression detection at 81.8% and specificity at 100%.

Sarajevo – Potential and Limitations in the Development of the City and Region

Observing through the historical prism of regional development and regionalization in Bosnia and Herzegovina, city and region of Sarajevo have special importance and significance. This is mainly due to the fact that the City of Sarajevo is the main administrative center, i.e. the center of political, economic, cultural and overall social life and development in Bosnia and Herzegovina. At the same time, the Sarajevo is the center of Canton of Sarajevo, the center of this macro-region, as well as it is the capital of the entity of the Federation and state of Bosnia and Herzegovina. All those facts make Sarajevo attractive both for life and business, furthermore for studying its capacity and development potentials as well.&#x0D; In modern economics, the regions represent an important development level, while regionalisation represent an essentional component of the political systems of the modern state. The regions have become a link between local and central (state) institutions of government and local and overall economic development of country. The Bosnia and Herzegovina has a long tradition of regionalization and regionalism. Over long time, it has gone through verious phases and forms of regionalisation depening on then chraging political order. Sarajevo as a city and the region has historicaly developed in two directions. First, towards the capital of state of Bosnia and Herzegovina and the main administrative center. Secondly, towards the center of the region, i.e. the macro-region. Sarajevo macro-region is the most developed region in Bosnia and Herzegovina in terms of overall infrastructure and resources bacause of its normative, social importance and the position of the city itself. The territory covered by the Sarajevo macro-region has significant natural resources, energy potentials, as well as resources for the development of industry. Truistically, along with Mostar, it is a most impressive destination for tourists. Nevertheless, this macroregion still does not fully exploit the resources available to it, due to the many limitations and obsticles that directly affect it and that require adequate resolution.

Novi nalazi i perspektive arheoloških istraživanja urbanog i upravnog središta municipija Aquae / New findings and perspectives of archaeological research of the urban and administrative c enter of the Aquae municipium

The introduction of this paper gives a short overview of the results of archaeological, historiographic, and epigraphic research of the Roman municipium Aquae. The urban center of the municipium Aquae was in Ilidža, one of nine municipalities of the Sarajevo Canton. In 2022, at the right bank of the Željeznica river, an unpublished Roman-period monument was recorded. Analysis has determined that this is a fragment of a tombstone (cippus) or an honorary inscription (tituli publici). Moreover, this paper addresses the issue of unregistered archaeological material from the Roman period that is recorded in the Željeznica riverbed and near previously corroborated archaeological sites in Ilidža. In this context, two fragments of honorary bases stand out. One of these fragments has preserved indentations that served to attach the statue or bust to the base. Finally, the paper includes maps made as the result of systematic research in 1979. This research was conducted by the Sarajevo City Institute for the Protection and Organization of Cultural Monuments (today’s Cantonal Institution for the Protection of Cultural, Historical and Natural Heritage of Sarajevo).

Development Of Digital Competences and Their Influence On Innovative Approaches In The Teaching Practice Of Students Of The Academy Of Fine Arts Of The University Of Sarajevo

The development of new technologies has a significant impact on many artistic fields, with work processes redefined and new digital tools can join analog ones to become a continuation of the creator's hand. The goal of this research is to determine the possibility of using digital and analog tools in art education. The research was conducted among students/future teachers, with the aim of determining the extent to which digital and analog tools are suitable for certain art design, and to examine the methodological specifics of the implementation of such classes. The research “Development of digital competences and their influence on innovative approaches in the teaching practice of students of the Academy of Fine Arts of the University of Sarajevo” foresees a series of activities, which require that students, through lectures, seminars and workshops, become familiar with new possibilities of digital and analog tools, and to implement the acquired knowledge in their teaching practice. The impact of the research is reflected in the strengthening of students’ output competencies, their preparation for independent activity in the primary educational context. Digital and analog tools, along with the application of the general laws of visual language, will have an empowering effect on students and future teachers, but also on the end users of the acquired knowledge, that is, on the students of Canton Sarajevo primary schools. The use of digital and analog tools for the purpose of creating an art solution will enable all participants of the research activities to develop a wide range of creative skills and expand their output digital competences, as well as easier design and construction of a personal art manuscript. The results of the research can be a real incentive for the modernization of the university education program, the lifelong training program for art teachers, and current and future teaching practices, which primarily want to respond to the challenges of social aspirations.

Influence of Forest Type and Climate Factors on the Number of Caught Ips typographus (Coleoptera, Curculionidae) Bark Beetles in Pheromone Traps in Protected Areas of Bosnia and Herzegovina

As part of the research, the population of the eight-toothed spruce bark beetle in different types of forests in five protected areas in Bosnia and Herzegovina was analyzed. The study focused on the protected areas of Sarajevo Canton, specifically the secondary forests of fir and spruce, as well as the mixed forests of beech and fir (containing spruce). Pheromone traps were used as the research sample, and they were placed within PA Bijambara, PA Trebević, and PA Skakavac. The objective was to investigate the influence of forest type and climatological factors on the number of captured Ips typographus bark beetles from 2018 to 2021. The average number of captured I. typographus bark beetles during that period ranged from 491.39 to 901.68 individuals in secondary fir and spruce forests, and from 201.88 to 701.54 individuals in beech and fir forests (including spruce).

ZNAČAJ KLASIČNE RADIOGRAFIJE PLUĆA U OTKRIVANJU TUBERKULOZE PLUĆA

ABSTRACT&#x0D;  &#x0D; Diagnostic radiology provides a non-invasive insight into the anatomy and physiology of the human body and is one of the most useful tools in modern medicine. Accelerated technological development has led to improved image quality and the ability to obtain additional diagnostic information necessary for accurate and rapid diagnostics. As in other fields of medicine, in diagnostic radiology, all elements of risk must be balanced against the benefits arising from the use of a given diagnostic method.&#x0D; Aim: study is to determine the age and gender structure of the subjects who came for radiographs, to prove whether the X-ray has a significant role in detecting lung tuberculosis, whether the radiological record matches the findings of a pneumophysiologist or whether a microbiological analysis is needed, and to determine whether tuberculosis detected by classical radiography is also proven.&#x0D; Prospective method included 50 adult respondents from the Public Health Center of the Canton of Sarajevo, of different age and gender structures, who performed radiographic pulmonary imaging and processing of pneumophysiological findings in the period from 01.01.2018. do 30.05.2019. years. X-rays were taken from the classic Siemens Multix X-ray machine. Patients' medical records, microbiological examination of sputum on BC, pneumophysiological findings, radiographs and radiological findings from the radiological information system and the PACS system were used for the data. We used a retrospective study that included descriptive statistics, standard deviation, arithmetic mean, and correlation coefficient.&#x0D; Results: show that there is no significant statistical difference by gender, the average age of the respondents was 50, 52 years. &#x0D; X-ray imaging as a diagnostic procedure is of great importance in the detection of pulmonary tuberculosis, and 72% of the subjects had pulmonary tuberculosis first compared with the findings of pneumophysiologists, and bacteriological analysis was used in 28% subjects due to suspected pneumophysiologists in the diagnosis. By comparing the correlation of the pneumophysiologist and the bacteriological analysis, the X-ray showed 100% lung tuberculosis.

Congenital malformations registered in the Federation of Bosnia and Herzegovina 2019-2021

Abstract Congenital malformations are defined as structural or functional anomalies that occur in utero or at birth and can be detected at an early age. They are also known as birth defects, disabilities or congenital malformations. Congenital malformations are accompanied by hereditary or developmental disabilities or disease. From the establishment of the registry in early 2019 until the end of 2021, the total number of reported congenital malformations is 449. According to available data from EUROCAT (European network of population-based registries for the epidemiological surveillance of congenital anomalies), the average rate of congenital malformations in the countries of the European Union (EU) is 262/per 10,000 live births, while the registered rate of congenital malformations in the Federation of Bosnia and Herzegovina is 261/per 10,000 live births. In the Federation of Bosnia and Herzegovina, the highest incidence rate was registered in Sarajevo Canton (175 cases with a rate of 416/10,000 live births) and Tuzla Canton (122 cases with a rate of 356/10,000 live births). The most common congenital malformations are heart defects, cleft lip and palate, musculoskeletal deformities and Down syndrome. In the Federation of Bosnia and Herzegovina (FBiH) in 2020, 135 children under the age of 5 died, among which 18 children (13.3%) died from congenital malformations, deformations and chromosomal abnormalities (Q00-Q99). Congenital malformations can lead to chronic diseases and disabilities, death of infants and children up to five years of age. Congenital malformations represent a significant public health problem, given that they lead to disability, incapacity and pressure on the health system, as well as the problem of social integration of patients. Key messages • The registered rate of congenital malformations in the Federation of Bosnia and Herzegovina is 261/per 10,000 live births. • Congenital malformations can lead to chronic diseases and disabilities, death of infants and children up to five years of age.

Correlation analysis of different optical remote sensing indices for drought monitoring: a case study of Canton Sarajevo, Bosnia and Herzegovina.

Droughts are second to hurricanes the world's most costly weather events. Damage caused by droughts in certain countries is measured in tens of billions of dollars per year. Timely detection of drought and prediction of its occurrence has the potential to reduce costs and save a large number of people from its consequences. Numerous methods that serve this purpose exist in scientific research and practice. One group of drought monitoring methods belongs to the field of remote sensing, where it is possible to monitor drought indicators over large areas in almost real-time through satellite images. This paper is focused on the optical indices of remote sensing calculated by raster algebra. The intention was to reach conclusions about the quality of individual indices used for the Canton Sarajevo area in Bosnia and Herzegovina for each month of August in the period 2008-2021 through correlational and qualitative analysis and the use of meteorological indicators. Among the used indices, NDVI (normalized difference vegetation index) and NMI (normalized moisture index) proved to be the most reliable, and their mutual correlation was very strong (r = 0.99).

PRIMJENA APLIKACIJSKOG SOFTVERA SWMM ZA UPRAVLJANJE URBANIM OBORINSKIM VODAMA

The paper presents a hydrological-hydraulic analysis of the impact of LID elements (LOW IMPACT DEVELOPMENT) for urban stormwater management using the SWMM (Storm Water Management Model) application software created only for this type of research. A hydrological model was created with the application of LID elements in the form of green roofs. at the Faculty of Architecture and Civil Engineering and related facilities (Institutes) in Sarajevo, Sarajevo Canton. For which the results of the calculation and estimation of the amount of water in the analyzed area are given. A concrete example showed the positive impact of the application of LID elements, i.e. green elements in urban areas in the function of flood protection and environmental protection.

IMPROVEMENT OF TECHNICAL MEASURES FOR PROCEDURES IN ACCIDENTS ON GAS SYSTEM

Due to properties as flammability, explosiveness, suffocation (decreased oxygen content), toxicity (incomplete combustion), large lengths of gas pipelines, risk of leakage, etc., natural gas is media that requires special care during transport and use. There are many examples in the world where unprofessional and negligent use of gas led to unimaginable and tragic consequences with human casualties and huge material damages. This paper analyzes management of accidental situations at the Sarajevo Canton gas system. Problematic aspects of management will be presented through two case studies instead of presenting idealized models that integrate all structures responsible for dealing with such accidental situations. The methodological approach in this paper is presented through selection of accidents on gas network that had a significant impact and required a coordinated response from the competent services. The goal is to consider possibilities of improving technical measures by installing valves with remote control, which would raise safety to a higher level. With this step forward in technical terms, it would be possible to close the valve on gas system in the shortest period of time by controlling it from the dispatch center, which would stop the uncontrolled gas release. The paper will suggest locations where it would be optimal to install valves with remote control, in order to close the necessary section, and at the same time, the least number of consumers would have a gas supply interruption. Key words: gas system, accident, technical measures

The relationship between body weight and health-related quality of life of postmenopausal women attended at primary health care in Sarajevo Canton, Bosnia and Herzegovina

Postmenopausal women are particularly affected by obesity. Although it is well documented that obesity is strongly associated with morbidity and mortality, less is known about the impact of obesity on health-related quality of life (HRQoL). The aim of this study was to investigate the relationship between body weight and the physical and mental components of health-related quality of life of the postmenopausal women attended at primary health care in Sarajevo Canton, Bosnia and Herzegovina. This cross-sectional study evaluated 200 postmenopausal women in two groups of 100 each (i.e. overweight/ obese and normal weight). The respondents were supposed to fill out a questionnaire that included questions about their age, years since menopause and the SF-36 questionnaire. Women were weighed and measured, and BMI was calculated. The mean values for the mental component summary were significantly lower in the overweight/obese (59.08±21.86) than in the normal weight group (67.05±19.02) (p=0.006). The mean values for the physical component summary were significantly lower in the overweight/obese (57.56 ±22.81) than in the normal weight group (67.38±21.85) (p=0.002). There was not significant relationship between body weight and the physical and mental components of health-related quality of life. Identification of predicting factors of HRQoL, such as body mass index can help to improve the HRQoL, of these women allowing planning practical interventions.

Systemic inflammatory indexes (NLR, DNLR, PLR and SII) role in predicting COVID-19 progression

Introduction: The coronavirus disease 2019 (COVID-19) pandemic has caused a worldwide emergency. The disease is characterized primarily by symptoms of the respiratory system, but also by systemic inflammation. Since the onset of the disease, there has been a need for biomarkers to predict the severity of the clinical picture and the outcome of the disease. The aim of this study is to evaluate systemic inflammatory markers for predicting severity of COVID-19. Methods: The study was conducted at the Sarajevo Canton Health Center on a total of 170 adults suffering from COVID-19. 70 subjects had mild clinical picture, while the control group consisted of 100 subjects with moderate clinical picture. The results of complete and differential blood counts, C-reactive protein (CRP), and systemic inflammatory indexes (SII) (neutrophil/lymphocyte ratio [NLR], derived NLR [dNLR], platelet/lymphocyte ratio [PLR], and SII) were used to compare the groups. IBM SPSS Ver. 23 was used for statistical analysis and data processing. Results: The proportion of male patients in the group with a milder clinical picture was higher than the proportion of male patients with a moderate clinical picture, p = 0.016. The values of leukocytes and neutrophils were higher in patients with a moderate clinical picture (p = 0.006 and p &lt; 0.001, respectively). The values of all inflammatory indexes (NLR, dNLR, PLR and SII) were higher in patients with a moderate clinical picture of COVID-19 than in patients with a mild clinical picture (p &lt; 0.001 for NLR, dNLR, and SII; p = 0.023 for PLR). In the research, patient age showed no correlation and CRP showed no correlation with SII. Conclusion: SII show higher values in patients with a moderate compared with a mild clinical picture of COVID-19. These parameters can be cost-effective and useful indicators in patient classification, diagnosis, and probably in monitoring patients with COVID-19.

Decisions of the Council of Ministers of Bosnia And Herzegovina as Sub-Laws in Comparison With Regulations of Governments

This paper researches the decisions of the Council of Ministers of Bosnia and Herzegovina as general sub-laws and compares them with regulations of governments on other levels of government in Bosnia and Herzegovina. The comparison of the decisions of the Council of Ministers is carried out with the regulations of the Government of the Federation and the Government of Sarajevo Canton, with the intention to determine that decisions of the Council of Ministers have in essence the same scope and subject of regulating as the aforementioned government regulations, placing emphasis on the constitutional distribution of competencies between state, entities and cantons. The original research has determined that the Council of Ministers carries out the majority of legislative activities with their decisions, but rulebooks and instructions also appear as sub-laws, which isn’t the case on federal and cantonal levels, where rulebooks and instructions are exclusively adopted by administrative bodies, although administrative bodies on the level of Bosnia and Herzegovina also adopt these types of legislation. It has been determined that most decisions, rulebooks and instructions of the Council of Ministers, as well as regulations of governments are adopted for the purpose of executing the law, therefore as classical sub-laws, although different examples also appear. Finally, an amendment to the law is proposed in the sense that the Council of Ministers adopts regulations as sub-laws, with the cessation of adoption of rulebooks and instructions, which would be more appropriate from the aspect of our administrative law and bring about more order and would systematise this area.

Evolution of seroprevalence to SARS-CoV-2 in blood donors in Sarajevo Canton, Federation of Bosnia and Herzegovina: Cross-sectional and longitudinal studies.

Sarajevo Canton in the Federation of Bosnia and Herzegovina has recorded several waves of high SARS-CoV-2 transmission and has struggled to reach adequate vaccination coverage. We describe the evolution of infection- and vaccine-induced SARS-CoV-2 antibody response and persistence. We conducted repeated cross-sectional analyses of blood donors aged 18-65 years in Sarajevo Canton in November-December 2020 and 2021. We analyzed serum samples for anti-nucleocapsid (anti-N) and anti-spike (anti-S) antibodies. To assess immune durability, we conducted longitudinal analyses of seropositive participants at 6 and 12 months. One thousand fifteen participants were included in Phase 1 (November-December 2020) and 1152 in Phase 2 (November-December 2021). Seroprevalence increased significantly from 19.2% (95% CI: 17.2%-21.4%) in Phase 1 to 91.6% (95% CI: 89.8%-93.1%) in Phase 2. Anti-S IgG titers were significantly higher among vaccinated (58.5%) than unvaccinated infected participants across vaccine products (p < 0.001), though highest among those who received an mRNA vaccine. At 6months, 78/82 (95.1%) participants maintained anti-spike seropositivity; at 12 months, 58/58 (100.0%) participants were seropositive, and 33 (56.9%) had completed the primary vaccine series within 6months. Among 11 unvaccinated participants who were not re-infected at 12 months, anti-S IgG declined from median 770.1 (IQR 615.0-1321.7) to 290.8 (IQR 175.7-400.3). Anti-N IgG antibodies waned earlier, from 35.4% seropositive at 6months to 24.1% at 12 months. SARS-CoV-2 seroprevalence increased significantly over 12 months from end of 2020 to end of 2021. Although individuals with previous infection may have residual protection, COVID-19 vaccination is vital to strengthening population immunity.

KAMPUS UNIVERZITETA U SARAJEVU – SMJERNICE RAZVOJA / UNIVERSITY OF SARAJEVO CAMPUS – DEVELOPMENT GUIDELINES

In cooperation with the Sarajevo Canton, the European Investment Bank, has been providing support to the drafting of a new University of Sarajevo Campus’ Master Plan. The project involves the commissioning of a master plan and a feasibility study, which will ultimately enable the spatial integration of various University of Sarajevo’s educational and scientific research units into single merged modern campus. The project task was carried out by the Campus Construction and Maintenance Directorate, in cooperation with the ARUP consulting company, based on an analysis of the current situation, existing planning solutions, adopted guidelines and real needs and interests expressed by the University of Sarajevo. The project assignment states, among other things, that the Campus development strategy must ensure improved working conditions for students and academic staff, as well as effective cooperation between faculties, academies and research institutes. An integral part of the Project Task is the Framework Study, the preparation of which was financed by the World Bank, and was made by the company ARUP based on the guidelines defined by the University of Sarajevo and the Sarajevo Canton. In the aforementioned study, the scope is divided into zones with different coefficients of construction and plot occupancy, and in addition to the planned construction of university facilities, one zone is intended for the construction of a university park.